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1

Activation of NADPH Oxidase in Alzheimer's Disease Brains

Shun Shimohama, Hiroko Tanino, Naoko Kawakami, Naoki Okamura, Hiroomi Kodama, Teruhide Yamaguchi, Takao Hayakawa, Akihiko Nunomura, Shigeru Chiba, George Perry, Mark A Smith, Sadaki Fujimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 122 KB

english, 2000

2

Role of mitochondrial dysfunction in Alzheimer's disease

Rudy Castellani, Keisuke Hirai, Gjumrakch Aliev, Kelly L. Drew, Akihiko Nunomura, Atsushi Takeda, Adam D. Cash, Mark E. Obrenovich, George Perry, Mark A. Smith

Journal:

Journal of Neuroscience Research

Year:

2002

Language:

english

File:

PDF, 283 KB

english, 2002

3

How important is oxidative damage? Lessons from Alzheimer’s disease

George Perry, Arun K Raina, Akihiko Nunomura, Takafumi Wataya, Lawrence M Sayre, Mark A Smith

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 44 KB

english, 2000

4

Amyloid-β, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?

Mark A Smith, Kelly L Drew, Akihiko Nunomura, Atsushi Takeda, Keisuke Hirai, Xiongwei Zhu, Craig S Atwood, Arun K Raina, Catherine A Rottkamp, Lawrence M Sayre, Robert P Friedland, George Perry

Journal:

Neurochemistry International

Year:

2002

Language:

english

File:

PDF, 56 KB

english, 2002

5

A suicide note from Alzheimer disease neurons?

Perry, George, Nunomura, Akihiko, Smith, Mark A.

Journal:

Nature Medicine

Year:

1998

File:

PDF, 252 KB

1998

6

Oxidative stress in Alzheimer’s disease

Mark A. Smith, Catherine A. Rottkamp, Akihiko Nunomura, Arun K. Raina, George Perry

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2000

Language:

english

File:

PDF, 333 KB

english, 2000

7

Oxidative stress hypothesis for Alzheimer’s disease and its potential therapeutic implications

Nunomura, Akihiko

Journal:

Rinsho Shinkeigaku

Year:

2013

File:

PDF, 634 KB

2013

8

Mitochondrial abnormalities: A primary basis for oxidative damage in Alzheimer's disease

Mark A. Smith, Keisuke Hirai, Akihiko Nunomura, George Perry

Journal:

Drug Development Research

Year:

1999

Language:

english

File:

PDF, 125 KB

english, 1999

9

In Alzheimer's Disease, Heme Oxygenase Is Coincident with Alz50, an Epitope of τ Induced by 4-Hydroxy-2-Nonenal Modification

Atsushi Takeda, Mark A. Smith, Jesus Avilá, Akihiko Nunomura, Sandra L. Siedlak, Xiongwei Zhu, George Perry, Lawrence M. Sayre

Journal:

Journal of Neurochemistry

Year:

2000

Language:

english

File:

PDF, 1.19 MB

english, 2000

10

Redox metals and oxidative abnormalities in human prion diseases

Robert B. Petersen, Sandra L. Siedlak, Hyoung-gon Lee, Yong-Sun Kim, Akihiko Nunomura, Fabrizio Tagliavini, Bernardino Ghetti, Patrick Cras, Paula I. Moreira, Rudy J. Castellani, Marin Guentchev, Herb

Journal:

Acta Neuropathologica

Year:

2005

Language:

english

File:

PDF, 450 KB

english, 2005

11

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

Rudy J. Castellani, Hyoung-Gon Lee, Xiongwei Zhu, Akihiko Nunomura, George Perry, Mark A. Smith

Journal:

Acta Neuropathologica

Year:

2006

Language:

english

File:

PDF, 426 KB

english, 2006

12

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

Akihiko Nunomura, Tim Hofer, Paula I. Moreira, Rudy J. Castellani, Mark A. Smith, George Perry

Journal:

Acta Neuropathologica

Year:

2009

Language:

english

File:

PDF, 532 KB

english, 2009

13

Indices of Metabolic Dysfunction and Oxidative Stress

Gemma Casadesus, Paula I. Moreira, Akihiko Nunomura, Sandra L. Siedlak, William Bligh-Glover, Elizabeth Balraj, Grace Petot, Mark A. Smith, George Perry

Journal:

Neurochemical Research

Year:

2007

Language:

english

File:

PDF, 172 KB

english, 2007

14

In Memoriam: Mark A. Smith, PhD: Neuroscientist and Visionary

Rudy J. Castellani, Xiongwei Zhu, Akihiko Nunomura, George Perry

Journal:

Year:

2011

Language:

english

File:

PDF, 158 KB

english, 2011

15

Neuronal RNA Oxidation in Alzheimer's Disease and Down's Syndrome

AKIHIKO NUNOMURA, GEORGE PERRY, KEISUKE HIRAI, GJUMRAKCH ALIEV, ATSUSHI TAKEDA, SHIGERU CHIBA, MARK A. SMITH

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 2.41 MB

english, 1999

16

The Role of Oxidative Stress in the Pathophysiology of Cerebrovascular Lesions in Alzheimer's Disease

Gjumrakch Aliev, Mark A. Smith, Dilara Seyidova, Maxwell Lewis Neal, Bruce T. Lamb, Akihiko Nunomura, Eldar K. Gasimov, Harry V. Vinters, George Perry, Joseph C. LaManna, Robert P. Friedland

Journal:

Brain Pathology

Year:

2002

Language:

english

File:

PDF, 281 KB

english, 2002

17

Oxidative Stress and Neurodegeneration

PAULA I. MOREIRA, MARK A. SMITH, XIONGWEI ZHU, AKIHIKO NUNOMURA, RUDY J. CASTELLANI, GEORGE PERRY

Journal:

Annals of the New York Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 2.33 MB

english, 2005

18

Oxidative Damage to RNA in Aging and Neurodegenerative Disorders

Akihiko Nunomura, Paula I. Moreira, Rudy J. Castellani, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, George Perry

Journal:

Neurotoxicity Research

Year:

2012

Language:

english

File:

PDF, 438 KB

english, 2012

19

Antioxidant approaches for the treatment of Alzheimer’s disease

Castellani, Rudy J, Nunomura, Akihiko, Smith, Mark A, Lee, Hyoung-gon, Perry, George, Lee, Hyun Pil, Zhu, Xiongwei, Casadesus, Gemma

Journal:

Expert Review of Neurotherapeutics

Year:

2010

Language:

english

File:

PDF, 359 KB

english, 2010

20

Abortive apoptosis in Alzheimer's disease

Arun K. Raina, Ayala Hochman, Xiongwei Zhu, Catherine A. Rottkamp, Akihiko Nunomura, Sandra L. Siedlak, Heather Boux, Rudolph J. Castellani, George Perry, Mark A. Smith

Journal:

Acta Neuropathologica

Year:

2001

Language:

english

File:

PDF, 311 KB

english, 2001

21

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

Quan Liu, Mark A. Smith, Jesus Avilá, John DeBernardis, Mayank Kansal, Atsushi Takeda, Xiongwei Zhu, Akihiko Nunomura, Kazuhiro Honda, Paula I. Moreira, Catarina R. Oliveira, Maria S. Santos, Shun Shi

Journal:

Free Radical Biology and Medicine

Year:

2005

Language:

english

File:

PDF, 450 KB

english, 2005

22

Amyloid-β, BACE, and oxidative stress in Alzheimer's disease, a commentary on “The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression”

Hyoung-gon Lee, George Perry, Xiongwei Zhu, Akihiko Nunomura, Mark A. Smith

Journal:

Free Radical Biology and Medicine

Year:

2006

Language:

english

File:

PDF, 72 KB

english, 2006

23

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-β peptide

Takaaki Hayashi, Naomi Shishido, Kenji Nakayama, Akihiko Nunomura, Mark A. Smith, George Perry, Masao Nakamura

Journal:

Free Radical Biology and Medicine

Year:

2007

Language:

english

File:

PDF, 350 KB

english, 2007

24

Nucleic acid oxidation in Alzheimer disease

Paula I. Moreira, Akihiko Nunomura, Masao Nakamura, Atsushi Takeda, Justin C. Shenk, Gjumrakch Aliev, Mark A. Smith, George Perry

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 356 KB

english, 2008

25

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

Akihiko Nunomura, Toshio Tamaoki, Koich Tanaka, Nobutaka Motohashi, Masao Nakamura, Takaaki Hayashi, Haruyasu Yamaguchi, Shun Shimohama, Hyoung-gon Lee, Xiongwei Zhu, Mark A. Smith, George Perry

Journal:

Neurobiology of Disease

Year:

2010

Language:

english

File:

PDF, 1.35 MB

english, 2010

26

Striation is the characteristic neuritic abnormality in Alzheimer disease

Manuel E. Velasco, Mark A. Smith, Sandra L. Siedlak, Akihiko Nunomura, George Perry

Journal:

Year:

1998

Language:

english

File:

PDF, 1.01 MB

english, 1998

27

Will antioxidants fulfill their expectations for the treatment of Alzheimer disease?

Catherine A Rottkamp, Akihiko Nunomura, Keisuke Hirai, Lawrence M Sayre, George Perry, Mark A Smith

Journal:

Mechanisms of Ageing and Development

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

28

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

Xiongwei Zhu, Rudolph J Castellani, Atsushi Takeda, Akihiko Nunomura, Craig S Atwood, George Perry, Mark A Smith

Journal:

Mechanisms of Ageing and Development

Year:

2001

Language:

english

File:

PDF, 364 KB

english, 2001

29

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases?

George Perry, Akihiko Nunomura, Keisuke Hirai, Xiongwei Zhu, Mar Prez, Jess Avila, Rudolph J Castellani, Craig S Atwood, Gjumrakch Aliev, Lawrence M Sayre, Atsushi Takeda, Mark A Smith

Journal:

Free Radical Biology and Medicine

Year:

2002

Language:

english

File:

PDF, 62 KB

english, 2002

30

Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

Rudy J Castellani, Mark A Smith, Akihiko Nunomura, Peggy L.R Harris, George Perry

Journal:

Free Radical Biology and Medicine

Year:

1999

Language:

english

File:

PDF, 293 KB

english, 1999

31

Kindling of the Mesencephalic Reticular Formation and Its Influence on Subsequent Amygdala Kindling in Rats.

Shigeru Chiba, Nobuyuki Omori, Shunsuke Kamata, Akihiko Nunomura, Fukuyasu Mutoh

Journal:

Year:

1996

Language:

english

File:

PDF, 206 KB

english, 1996

32

Systemic Increase of Oxidative Nucleic Acid Damage in Parkinson's Disease and Multiple System Atrophy

Akio Kikuchi, Atsushi Takeda, Hiroshi Onodera, Teiko Kimpara, Kinya Hisanaga, Nobuyuki Sato, Akihiko Nunomura, Rudy J. Castellani, George Perry, Mark A. Smith, Yasuto Itoyama

Journal:

Neurobiology of Disease

Year:

2002

Language:

english

File:

PDF, 58 KB

english, 2002

33

Apolipoprotein E polymorphism and susceptibility to early- and late-onset sporadic Alzheimer's disease in Hokkaido, the northern part of Japan

Akihiko Nunomura, Shigeru Chiba, Masaaki Eto, Mieko Saito, Isao Makino, Tsutomu Miyagishi

Journal:

Neuroscience Letters

Year:

1996

Language:

english

File:

PDF, 357 KB

english, 1996

34

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

Rudy J Castellani, Kazuhiro Honda, Xiongwei Zhu, Adam D Cash, Akihiko Nunomura, George Perry, Mark A Smith

Journal:

Ageing Research Reviews

Year:

2004

Language:

english

File:

PDF, 70 KB

english, 2004

35

Tau modifiers as therapeutic targets for Alzheimer's disease

Quan Liu, Hyoung-gon Lee, Kazuhiro Honda, Sandra L. Siedlak, Peggy L.R. Harris, Adam D. Cash, Xiongwei Zhu, Jesús Avila, Akihiko Nunomura, Atsushi Takeda, Mark A. Smith, George Perry

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2005

Language:

english

File:

PDF, 198 KB

english, 2005

36

Mitochondria: A therapeutic target in neurodegeneration

Paula I. Moreira, Xiongwei Zhu, Xinglong Wang, Hyoung-gon Lee, Akihiko Nunomura, Robert B. Petersen, George Perry, Mark A. Smith

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2010

Language:

english

File:

PDF, 453 KB

english, 2010

37

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

Hyoung-gon Lee, George Perry, Paula I. Moreira, Matthew R. Garrett, Quan Liu, Xiongwei Zhu, Atsushi Takeda, Akihiko Nunomura, Mark A. Smith

Journal:

Trends in Molecular Medicine

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

38

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

Akihiko Nunomura, Shigeru Chiba, Carol F. Lippa, Patrick Cras, Rajesh N. Kalaria, Atsushi Takeda, Kazuhiro Honda, Mark A. Smith, George Perry

Journal:

Neurobiology of Disease

Year:

2004

Language:

english

File:

PDF, 1.15 MB

english, 2004

39

Chronological primacy of oxidative stress in Alzheimer disease

Mark A. Smith, Akihiko Nunomura, Hyoung-gon Lee, Xiongwei Zhu, Paula I. Moreira, Jesús Avila, George Perry

Journal:

Neurobiology of Aging

Year:

2005

Language:

english

File:

PDF, 49 KB

english, 2005

40

Oxidative stress in Alzheimer disease: A possibility for prevention

David J. Bonda, Xinglong Wang, George Perry, Akihiko Nunomura, Massimo Tabaton, Xiongwei Zhu, Mark A. Smith

Journal:

Neuropharmacology

Year:

2010

Language:

english

File:

PDF, 159 KB

english, 2010

41

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

Adam D. Cash, Gjumrakch Aliev, Sandra L. Siedlak, Akihiko Nunomura, Hisashi Fujioka, Xiongwei Zhu, Arun K. Raina, Harry V. Vinters, Massimo Tabaton, Anne B. Johnson, Manuel Paula-Barbosa, Jesus Avíla,

Journal:

The American Journal of Pathology

Year:

2003

Language:

english

File:

PDF, 268 KB

english, 2003

42

Amyloid-β junkies

George Perry, Akihiko Nunomura, Arun K Raina, Mark A Smith

Journal:

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

43

The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease

Catherine A Rottkamp, Craig S Atwood, James A Joseph, Akihiko Nunomura, George Perry, Mark A Smith

Journal:

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

44

Mitochondrial abnormalities in Alzheimer disease

George Perry, Keisuke Hirai, Gjumrakch Aliev, Akihiko Nunomura, Sandra L. Siedlak, Mark A. Smith

Journal:

Neurobiology of Aging

Year:

2000

Language:

english

File:

PDF, 178 KB

english, 2000

45

S4-02-04 Oxidative stress in Alzheimer's disease: the earliest event and an attractive therapeutic target

Akihiko Nunomura

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

46

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

Rudy J Castellani, George Perry, Sandra L Siedlak, Akihiko Nunomura, Shun Shimohama, Jing Zhang, Thomas Montine, Lawrence M Sayre, Mark A Smith

Journal:

Neuroscience Letters

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

47

Oxidative damage in Alzheimer’s disease: the metabolic dimension

George Perry, Akihiko Nunomura, Keisuke Hirai, Atsushi Takeda, Gjumrakch Aliev, Mark A Smith

Journal:

International Journal of Developmental Neuroscience

Year:

2000

Language:

english

File:

PDF, 144 KB

english, 2000

48

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

George Perry, Marta A. Taddeo, Akihiko Nunomura, Xiongwei Zhu, Tania Zenteno-Savin, Kelly L. Drew, Shun Shimohama, Jesús Avila, Rudolph J. Castellani, Mark A. Smith

Journal:

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

Year:

2002

Language:

english

File:

PDF, 308 KB

english, 2002

49

Amyloid-β Vaccination: Testing the Amyloid Hypothesis?: Heads We Win, Tails You Lose!

Hyoung-gon Lee, Xiongwei Zhu, Akihiko Nunomura, George Perry, Mark A. Smith

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 175 KB

english, 2006

50

The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse

Hyoung-gon Lee, Gemma Casadesus, Akihiko Nunomura, Xiongwei Zhu, Rudy J. Castellani, Sandy L. Richardson, George Perry, Dean W. Felsher, Robert B. Petersen, Mark A. Smith

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 674 KB

english, 2009